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As the most important study design among the primary studies, the clinical trials account for a major part of clinical research. A clinical trial involves researches that aim to address a scientific question in specific population to assess the safety and potential benefits of an intervention, such as medication, medical device, or equipment. Most clinical trials are performed to evaluate the safety, efficacy, and effectiveness of new drugs, devices, or methods. Typically, researchers first test new treatment or intervention on animals in the laboratory. New treatments or intervention that yield positive results are transferred to clinical trials. However, these new treatments or intervention often require several testing phases to finally approve by legislative organizations.

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